Neal L. Weintraub, M.D.
Professor, Cardiovascular Medicine
Phone: (706) 721-6164
Fax: (706) 721-9799
Office: CB-3330C / Lab: CB-3301
Dr. Weintraub’s laboratory is focused on vascular biology research with emphasis on oxidative stress, inflammation, and obesity. In particular, his work has advanced the understanding of the role of inflammation and oxidative stress in the pathogenesis of atherosclerosis and aortic aneurysm disease. Through collaborations, the laboratory also participates in research related to remote cardioprotection and stem cell-mediated therapy of the heart. As a clinician, Dr. Weintraub conducts various clinical research projects, including early stage translational research in humans that is derived from the basic science laboratory.
Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms: focused on myeloperoxidase-mediated oxidative stress and therapeutic interruption with niacin. Upstream (GPR109a) and downstream (DP receptor) pathways are also under investigation.
Role of perivascular adipose tissue (PVAT) in the pathogenesis of atherosclerosis: studies are performed using human perivascular adipocytes, and we have developed a novel model of PVAT transplantation into mice.
Role of histone deacetylase-9 in the pathogenesis of obesity-related disease (project headed by Dr. Tapan Chatterjee). This project investigates epigenetic mechanisms of adipose tissue dysfunction in obesity.
Impact of high fat diet on the biology of red blood cells, with an emphasis on the Duffy Antigen Receptor for Chemokines (DARC)- in collaboration with Drs. Julia Brittain and Ryan Harris.
Active Grant Support
“Perivascular adipose tissue and vascular remodeling” PI: Weintraub, NL. NHLBI (R01HL112640) 07/13/2012 - 06/30/2017.
“Antigotensin II, Oxidative Stress and Aneurysm Formation” PI: Weintraub, NL. NHLBI (R01HL076684) 2/01/2010 – 1/31/2014.
"LDL Receptor Related Protein-1 in Metabolic and Cardiovascular Disease Modulation” PI: Hui,D. CoI: Weintraub, NL. NIDDK (R01DK074932) 2/5/2011 - 1/31/2016.
1977-1978 University Scholars Program, Tulane University
1977-1979 Freshman Honor Premedical Society, Tulane University
1983 Alpha Omega Alpha, Tulane University
1986-1987 Resident of the Year Award, University of Illinois College of Medicine, Urbana-Champaign
1987-1988 Raymond B. Allen Instructorship (Golden Apple Teaching Award), University of Illinois College of Medicine
1988-1989 Raymond B. Allen Instructorship (Golden Apple Teaching Award), University of Illinois College of Medicine
1991-1992 Cardiovascular Fellow of the Year Award, Saint Louis University School of Medicine
1994 American College of Cardiology/Bristol-Myers Squibb Affiliate Travel Award, Atlanta, GA
1994-1995 Affiliate-in-Training Representative, Am. Coll. Of Cardiology
1995 Senior Fellow Achievement Award, Cardiology Division, St. Louis University School of Medicine
2002, 2004, 2005 Above and Beyond Award, University of Iowa Hospitals and Clinics
2007-2012 “Best Doctors in America”
2007-2012 “Cincinnati’s Best Doctors”
2013 GRA Herbert S. Kupperman M.D. Eminent Scholar in Cardiovascular Medicine
“Perivascular adipocyte dysfunction: a new concept in atherosclerosis.” Invited talk, Medical College of Wisconsin, December, 2008.
“Harnessing the power of the skin to protect the heart and other organs from ischemic injury”. University of Cincinnati, Internal Medicine Ground Rounds, July 2009.
“Turning atherosclerosis inside out: role of perivascular adipose tissue”. Invited talk, Aab Cardiovascular Research Institute (CVRI), Rochester, NY, March, 2011.
“Turning atherosclerosis inside out: role of perivascular adipose tissue”. Invited talk, Beth Israel Deaconess Medical School, Boston, MA, April, 2011.
“Turning atherosclerosis inside out: role of perivascular adipose tissue”. Invited talk, University of Louisville Cardiovascular Medicine Grand Rounds, Louisville, KY, November, 2011.
“Role of histone deacetylase-9 in adipocyte differentiation and diet-induced obesity”. Invited talk, University of Kentucky College of Medicine, Lexington, KY, April, 2012.
“Ischemic postconditioning: past, present and future”. Invited talk, University of Iowa Cardiovascular Medicine CME Symposium and Cardiology Fellow Society Meeting, Iowa City, IA, June, 2012.
“Role of histone deacetylase-9 in adipocyte differentiation and diet-induced obesity”. Invited talk, Georgia Health Sciences University, June, 2012.
“Oxidative stress as a target for pharmacotherapy in abdominal aortic aneurysm.” Invited talk, Boston University, November 2013.
Nicole Yiew, PhD student (pharmacology) 11/2013-
Rod Pellenberg, MD, postdoctoral fellow 9/2013-
Meaghann Waltman, PhD student (pathobiology, University of Cincinnati), 2009-2013
Journal ArticlesPubMed search for "weintraub nl" [au] +
Weintraub, N.L., Stephenson, A.H., Sprague, R.S., and Lonigro, A.J.: Role of phospholipase A2 in EDHF-mediated relaxation of the porcine coronary artery. In: Endothelium-Dependent Hyperpolarizations, P.M. Vanhoutte (Ed.), Canada, Harwood Academic Publishing, pp. 97-108, 1999.
Chu, Y., Weintraub, N., and Heistad, D.D.: Gene therapy and cardiovascular disease. In: Principles of Molecular Cardiology. M.S. Runge, and C. Patterson, (Eds). Totowa, NJ, Humana Press, pp. 57-69, 2005.
Sanchez CE, Kapur S, Weintraub NL. Aneurysms (large and small arteries). In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (6th Edition). Pp. 870-882. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphilia, PA, 2012.
Education & Training
Saint Louis University: Postdoctoral Research Fellow, National Research Service Award, Clinical Pharmacology, 1992-1994
Saint Louis University: Fellow Cardiovascular Diseases, 1991-1995
University of Illinois, Urbana-Champaign, Illinois: Internal Medicine Resident (PGY-3), 1986-1987
Emory University: Internal Medicine Resident (PGY-1 & 2), 1984-1986
Tulane University: M.D., 1984
Tulane University: 1977-1980 Biology major
Research Experience & Academic Appointments
Associate Director, Vascular Biology Center, Georgia Regents University (2013-Present)
Professor of Medicine (with tenure), Kupperman Eminent Scholar in Cardiovascular Medicine, Georgia Regents University (2013-Present)
Co-director, Cardiovascular Center of Excellence, University of Cincinnati College of Medicine (2008-2013)
Stonehill Professor of Medicine (with tenure) and Director, Cardiovascular Division, University of Cincinnati College of Medicine, Cincinnati, Ohio (2006-2013)
Medical Director, UI Heart Care, University of Iowa College of Medicine (2005-2006)
Professor, Free Radical and Radiation Biology Graduate Program with the Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa(2005-2006
Professor of Medicine (with tenure), Cardiology Division, University of Iowa College of Medicine, Iowa City, Iowa (2005-2006)
Interim Director, Cardiology Division, University of Iowa College of Medicine (2003-2005)
Associate Professor, Free Radical and Radiation Biology Graduate Program with the Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa (2002-2005)
Associate Professor of Medicine (with tenure), Cardiology Division University of Iowa College of Medicine, Iowa City, Iowa (2001-2005)
Assistant Professor of Medicine, Cardiology Division,University of Iowa College of Medicine, Iowa City, Iowa (1996-2001)
Associate, Cardiology Division, University of Iowa College of Medicine, Iowa City, Iowa (1995-1996)
Staff Physician, VA Medical Center, Iowa City, IA (1995-2006)
Assistant Professor of Clinical Medicine, St. Louis University (1990-1991)
Staff Physician, VA Medical Center, St. Louis, Missouri (1990-1991)
Assistant Clinical Professor of Medicine, University of Illinois College of Medicine, Urbana-Champaign, Illinois (1988-1990)
Staff Physician, VA Medical Center, Danville, Illinois (1987-1990)
Clinical Instructor of Medicine, University of Illinois College of Medicine, Urbana-Champaign, Illinois (1987-1988)
President, Central Society for Clinical Research 2012-2013)
President Elect, Central Society for Clinical Research (2010-2011)
Vice President, Central Society for Clinical Research (2009-2010)
Councilor, Central Society for Clinical Research(2007-2009)
Member, American Federation for Medical Research(2000-2003)
Fellow, American Heart Association Council on High Blood Pressure Research (1999-2002)
Fellow, American College of Cardiology (1998-present)
American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (1998-present)
American Physiologic Society (1998-present)
Central Society for Clinical Research (1997-present)
American College of Cardiology (1991-present)
Missouri Chapter of ACC, Affiliate-in-Training representative (1994-1995)
Chair, American Heart Association Writing Committee on emergent management of acute decompensated heart failure (2010-2011)
Chair, Ohio Mission:Lifeline Public Education Workgroup, American Heart Association (2009-2011)
American Heart Association National Meeting- speaker, session moderator, abstract grader
Arteriosclerosis, Thrombosis and Vascular Biology Meeting- speaker
Society of Toxicolog- speaker
Central Society for Clinical and Translational Research
Editorial Board: Arteriosclerosis, Thrombosis and Vascular Biology (1999-present)
Reviewer (manuscripts): Circulation Research; Am J Physiol; Arteriosclerosis, Thrombosis and Vascular Biology; Cardiovascular Research; Circulation; Lipids; JPET; Hypertension; J Am Coll Cardiol
NIH AICS (Chair) (2011-2013)
NIH AICS (charter member) (2008-2013)
NIH AICS (temporary member) (2006)
VA Merit Cardiovascular Studies B (2004-2005)
NIH VCMB (2003-2005)
AHA CV Regulation II (2002-2003)
NIH CVB (2002)
NIH CCVS (2001)
NIH PPG review (Ruderman PPG) (2001)
AHA GRA-3B (2001-2002)
NIH ALTX4 (1999)
Ad Hoc reviewer of VA Merit Review grants (1999)
Member, IRB-A, Georgia Regents University (2013)
Member, MCG Strategic Plan Research Workgroup (2013)
Co-chair Strategic Planning Committee for UC Cardiovascular Institute (2011)
PPG External Oversight Committee, Mechanisms of Abdominal Aortic Aneurysm Formation, HL080100, PI Alan Daugherty, University of Kentucky (2008-2009)
Opthalmology Search Committee (2005)
New Clinical Initiatives Committee, UIHC (2004)
UIHC Pharmacy and Therapeutics Committee (2002-06)
Department of Internal Medicine Promotions Committee (2002-04)
College of Medicine Research Committee (2001-06)